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Anti-inflammatory phenylpropanoid glycosides from the fruits of Forsythia suspensa.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2019 Oct 01; Vol. 29 (19), pp. 126635. Date of Electronic Publication: 2019 Aug 23. - Publication Year :
- 2019
-
Abstract
- Five new phenylpropanoid glycosides, susaroysides A-E (1-5) were isolated from the fruits of Forsythia suspensa. Their structures were elucidated by comprehensive spectroscopic data analysis. The absolute configurations of their sugars were determined by GC analysis. Notably, susaroysides A-D possessed a sugar with an unsubstituted anomeric carbon, which is relatively rare in natural sources. Compound 1 exhibited significant anti-inflammatory activity against the lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α expression in macrophage cells with the IC <subscript>50</subscript> value of 1.053 μM.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Subjects :
- Humans
Lipopolysaccharides pharmacology
Macrophages cytology
Macrophages immunology
Macrophages metabolism
Phenols chemistry
Propanols chemistry
Anti-Inflammatory Agents pharmacology
Forsythia chemistry
Fruit chemistry
Glycosides pharmacology
Macrophages drug effects
Plant Extracts pharmacology
Tumor Necrosis Factor-alpha metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 29
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 31473042
- Full Text :
- https://doi.org/10.1016/j.bmcl.2019.126635