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Dendrobium officinale polysaccharides alleviate colon tumorigenesis via restoring intestinal barrier function and enhancing anti-tumor immune response.
- Source :
-
Pharmacological research [Pharmacol Res] 2019 Oct; Vol. 148, pp. 104417. Date of Electronic Publication: 2019 Aug 29. - Publication Year :
- 2019
-
Abstract
- Intact epithelial barrier and mucosal immune system are crucial for maintaining intestinal homeostasis. Previous study indicated that Dendrobium officinale polysaccharides (DOPS) can regulate immune responses and inflammation to alleviate experimental colitis. However, it remains largely unknown whether DOPS can suppress AOM/DSS-induced colorectal cancer (CRC) model through its direct impact on intestinal barrier function and intestinal mucosal immunity. Here, we demonstrated the therapeutic action of DOPS for CRC model and further illustrated its underlying mechanisms. Treatment with 5-aminosalicylic acid (5-ASA) and DOPS significantly improved the clinical signs and symptoms of chronic colitis, relieve colon damage, suppress the formation and growth of colon tumor in CRC mice. Moreover, administration of DOPS effectively preserved the intestinal barrier function via reducing the loss of zonula occludens-1 (ZO-1) and occludin in adjacent tissues and carcinomatous tissues. Further studies demonstrated that DOPS improved the metabolic ability of tumor infiltrated CD8 <superscript>+</superscript> cytotoxic T lymphocytes (CTLs) and reduced the expression of PD-1 on CTLs to enhance the anti-tumor immune response in the tumor microenvironments (TME). Together, the conclusions indicated that DOPS restore intestinal barrier function and enhance intestinal anti-tumor immune response to suppress CRC, which may be a novel strategy for the prevention and treatment of CRC.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
CD8-Positive T-Lymphocytes drug effects
CD8-Positive T-Lymphocytes metabolism
Colitis drug therapy
Colitis metabolism
Colon metabolism
Colorectal Neoplasms metabolism
Inflammation drug therapy
Inflammation metabolism
Intestinal Mucosa metabolism
Male
Mesalamine pharmacology
Mice
Mice, Inbred BALB C
Occludin metabolism
Signal Transduction drug effects
Tumor Microenvironment drug effects
Zonula Occludens-1 Protein metabolism
Antineoplastic Agents pharmacology
Carcinogenesis drug effects
Colon drug effects
Colorectal Neoplasms drug therapy
Dendrobium chemistry
Intestinal Mucosa drug effects
Polysaccharides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1096-1186
- Volume :
- 148
- Database :
- MEDLINE
- Journal :
- Pharmacological research
- Publication Type :
- Academic Journal
- Accession number :
- 31473343
- Full Text :
- https://doi.org/10.1016/j.phrs.2019.104417