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Glial Fibrillary Acidic Protein (GFAP) Autoimmunity in the Setting of Seropositive Rheumatoid Arthritis Treated With Etanercept.
- Source :
-
The neurologist [Neurologist] 2019 Sep; Vol. 24 (5), pp. 152-154. - Publication Year :
- 2019
-
Abstract
- Introduction: Glial fibrillary acidic protein (GFAP) immunoglobulin G is a recently discovered biomarker of an autoimmune central nervous system disorder characterized by a steroid-responsive meningoencephalomyelitis.<br />Case Report: A 63-year-old man with rheumatoid arthritis on etanercept presented with steroid-responsive subacute encephalopathy and foot drop. Brain and sural nerve biopsies demonstrated a T-cell perivascular infiltrate. Cerebrospinal fluid studies 18 months into the course of the illness demonstrated a GFAP antibody on mouse tissue immunofluorescence confirmed by cell-based assay. The patient was treated with steroids and cyclophosphamide leading to resolution of his symptoms.<br />Conclusion: This case expands on the previously reported cases of GFAP immunoglobulin G autoimmunity by describing an associated inflammatory large fiber peripheral neuropathy.
- Subjects :
- Autoimmunity
Brain Diseases complications
Humans
Immunoglobulin G
Male
Middle Aged
Peripheral Nervous System Diseases complications
Peripheral Nervous System Diseases immunology
Antirheumatic Agents adverse effects
Arthritis, Rheumatoid drug therapy
Arthritis, Rheumatoid immunology
Brain Diseases immunology
Etanercept adverse effects
Glial Fibrillary Acidic Protein immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2331-2637
- Volume :
- 24
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The neurologist
- Publication Type :
- Academic Journal
- Accession number :
- 31478999
- Full Text :
- https://doi.org/10.1097/NRL.0000000000000243