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Lyophilized Maqui ( Aristotelia chilensis ) Berry Induces Browning in the Subcutaneous White Adipose Tissue and Ameliorates the Insulin Resistance in High Fat Diet-Induced Obese Mice.

Authors :
Sandoval V
Femenias A
Martínez-Garza Ú
Sanz-Lamora H
Castagnini JM
Quifer-Rada P
Lamuela-Raventós RM
Marrero PF
Haro D
Relat J
Source :
Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2019 Sep 01; Vol. 8 (9). Date of Electronic Publication: 2019 Sep 01.
Publication Year :
2019

Abstract

Maqui ( Aristotelia Chilensis ) berry features a unique profile of anthocyanidins that includes high amounts of delphinidin-3-O-sambubioside-5-O-glucoside and delphinidin-3-O-sambubioside and has shown positive effects on fasting glucose and insulin levels in humans and murine models of type 2 diabetes and obesity. The molecular mechanisms underlying the impact of maqui on the onset and development of the obese phenotype and insulin resistance was investigated in high fat diet-induced obese mice supplemented with a lyophilized maqui berry. Maqui-dietary supplemented animals showed better insulin response and decreased weight gain but also a differential expression of genes involved in de novo lipogenesis, fatty acid oxidation, multilocular lipid droplet formation and thermogenesis in subcutaneous white adipose tissue (scWAT). These changes correlated with an increased expression of the carbohydrate response element binding protein b ( Chrebpb ), the sterol regulatory binding protein 1c ( Srebp1c ) and Cellular repressor of adenovirus early region 1A-stimulated genes 1 ( Creg1 ) and an improvement in the fibroblast growth factor 21 (FGF21) signaling. Our evidence suggests that maqui dietary supplementation activates the induction of fuel storage and thermogenesis characteristic of a brown-like phenotype in scWAT and counteracts the unhealthy metabolic impact of an HFD. This induction constitutes a putative strategy to prevent/treat diet-induced obesity and its associated comorbidities.

Details

Language :
English
ISSN :
2076-3921
Volume :
8
Issue :
9
Database :
MEDLINE
Journal :
Antioxidants (Basel, Switzerland)
Publication Type :
Academic Journal
Accession number :
31480627
Full Text :
https://doi.org/10.3390/antiox8090360