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Striatal Glutathione in First-episode Psychosis Patients Measured In Vivo with Proton Magnetic Resonance Spectroscopy.
- Source :
-
Archives of medical research [Arch Med Res] 2019 May; Vol. 50 (4), pp. 207-213. Date of Electronic Publication: 2019 Sep 26. - Publication Year :
- 2019
-
Abstract
- Deficits of brain glutathione (GSH), the most abundant and primary antioxidant in living tissue, and associated redox imbalance are postulated to be implicated in schizophrenia. This pilot clinical study compared the levels of striatal GSH, measured in vivo with proton magnetic resonance spectroscopy ( <superscript>1</superscript> H MRS) at 3T, in 10 drug-naïve, first-episode psychosis (FEP) patients with those in 9 matched healthy control subjects. The results revealed a significant GSH deficit in FEP patients (0.92 ± 0.24 × 10 <superscript>-3</superscript> ) compared to the healthy control group (1.10 ± 0.10 × 10 <superscript>-3</superscript> ) (U = 25.00, p = 0.02), as well as a positive correlation between GSH levels and the Positive Symptoms subscale of the PANSS in the FEP group (ρ = 0.96; p <0.001). These preliminary findings suggest a possible role of striatal oxidative stress in early-stage psychosis that warrants further scrutiny and confirmation in larger studies.<br /> (Copyright © 2019 IMSS. Published by Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-5487
- Volume :
- 50
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Archives of medical research
- Publication Type :
- Academic Journal
- Accession number :
- 31499481
- Full Text :
- https://doi.org/10.1016/j.arcmed.2019.08.003