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Combining Carbon Nanotubes and Chitosan for the Vectorization of Methotrexate to Lung Cancer Cells.

Authors :
Cirillo G
Vittorio O
Kunhardt D
Valli E
Voli F
Farfalla A
Curcio M
Spizzirri UG
Hampel S
Source :
Materials (Basel, Switzerland) [Materials (Basel)] 2019 Sep 06; Vol. 12 (18). Date of Electronic Publication: 2019 Sep 06.
Publication Year :
2019

Abstract

A hybrid system composed of multi-walled carbon nanotubes coated with chitosan was proposed as a pH-responsive carrier for the vectorization of methotrexate to lung cancer. The effective coating of the carbon nanostructure by chitosan, quantified (20% by weight) by thermogravimetric analysis, was assessed by combined scanning and transmission electron microscopy, and X-ray photoelectron spectroscopy (N1 s signal), respectively. Furthermore, Raman spectroscopy was used to characterize the interaction between polysaccharide and carbon counterparts. Methotrexate was physically loaded onto the nanohybrid and the release profiles showed a pH-responsive behavior with higher and faster release in acidic (pH 5.0) vs. neutral (pH 7.4) environments. Empty nanoparticles were found to be highly biocompatible in either healthy (MRC-5) or cancerous (H1299) cells, with the nanocarrier being effective in reducing the drug toxicity on MRC-5 while enhancing the anticancer activity on H1299.

Details

Language :
English
ISSN :
1996-1944
Volume :
12
Issue :
18
Database :
MEDLINE
Journal :
Materials (Basel, Switzerland)
Publication Type :
Academic Journal
Accession number :
31500165
Full Text :
https://doi.org/10.3390/ma12182889