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Preparation of Stereodefined 2-(3-Oxoindolin-2-yl)-2-Arylacetonitriles via One-Pot Reaction of Indoles with Nitroalkenes.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2019 Oct 04; Vol. 84 (19), pp. 12420-12429. Date of Electronic Publication: 2019 Sep 18. - Publication Year :
- 2019
-
Abstract
- Recently discovered reactivity of nitrostyrenes in phosphorous acid to facilitate the diastereoselective [4 + 1]-cycloaddition of indoles in combination with unusual oxazoline ring cleavage and subsequent 1,2-alkyl shift afforded stereochemically defined 2-(3-oxoindolin-2-yl)-2-arylacetonitriles as sole products.
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 84
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 31502836
- Full Text :
- https://doi.org/10.1021/acs.joc.9b01874