Double Pituitary Adenomas with Synchronous Somatotroph and Corticotroph Clinical Presentation of Acromegaly and Cushing's Disease.

Authors :: Collazo-Gutiérrez N
de Jesús O
Villamil-Jarauta M
Alvarado M
González L
Ramírez M
Carlo-Chevere VJ
Source :: World neurosurgery [World Neurosurg] 2019 Dec; Vol. 132, pp. 161-164. Date of Electronic Publication: 2019 Sep 07.
Publication Year :: 2019
Abstract: Background: Double pituitary adenomas are a rare occurrence. Synchronous clinical manifestation is extremely rare.<br />Case Description: We report a case of a 51-year-old female with symptoms of both hypercortisolism and acromegaly during the past 2 years. Endocrine evaluation confirmed active acromegaly and revealed adrenocorticotropin hormone-dependent hypercortisolemia. Preoperative magnetic resonance imaging of the pituitary demonstrated separated double microadenomas with different intensity. Immunohistochemical analysis of each separate adenoma confirmed an exact diagnosis. The diagnosis of acromegaly and adrenocorticotropin hormone-dependent Cushing's disease was confirmed.<br />Conclusions: This is the third reported case in the literature of synchronous clinical manifestation of acromegaly and Cushing's disease. Extensive surgical exploration of the sella must be performed to avoid surgical failures from residual tumor. Immunohistochemical analysis is required to confirm an exact diagnosis for each of the double pituitary adenomas.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)

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