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Immune recovery uveitis in a patient with herpes retinitis as a complication of hairy cell leukaemia.
- Source :
-
Archivos de la Sociedad Espanola de Oftalmologia [Arch Soc Esp Oftalmol (Engl Ed)] 2019 Nov; Vol. 94 (11), pp. 545-550. Date of Electronic Publication: 2019 Sep 07. - Publication Year :
- 2019
-
Abstract
- A 51 year-old man with hairy cell leukaemia was treated with pentostatin. While receiving the treatment, he was diagnosed with herpes retinitis in his right eye. After the last cycle of pentostatin the patient developed a mild vitritis and cystoid macular oedema. There were no signs of herpes retinitis reactivation. After excluding other possible causes of intraocular inflammation, a diagnosis of immune recovery uveitis was made. The patient was treated with 2-monthly retro-septal injections of triamcinolone, oral corticosteroids, intravitreal dexamethasone implants and, finally, pars plana vitrectomy. An immune recovery uveitis-like response is possible in HIV negative individuals. The immune reconstitution after the treatment of hairy cell leukaemia may have led to intraocular inflammation. Management of immune recovery uveitis is challenging and difficult. Pars plana vitrectomy may be necessary. Ophthalmologists should be alert to the possibility of immune recovery uveitis in HIV negative patients.<br /> (Copyright © 2019 Sociedad Española de Oftalmología. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Subjects :
- Antineoplastic Agents therapeutic use
Humans
Immune Reconstitution Inflammatory Syndrome diagnosis
Leukemia, Hairy Cell drug therapy
Male
Middle Aged
Pentostatin therapeutic use
Uveitis diagnosis
Visual Acuity
Herpesviridae Infections
Immune Reconstitution Inflammatory Syndrome immunology
Leukemia, Hairy Cell complications
Retinitis virology
Uveitis immunology
Subjects
Details
- Language :
- English; Spanish; Castilian
- ISSN :
- 2173-5794
- Volume :
- 94
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Archivos de la Sociedad Espanola de Oftalmologia
- Publication Type :
- Academic Journal
- Accession number :
- 31506207
- Full Text :
- https://doi.org/10.1016/j.oftal.2019.07.012