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Retrospective analysis of clinical features and treatment outcomes of children with Hodgkin's Lymphoma treated with different chemotherapy protocols at a tertiary care center in Pakistan.
- Source :
-
JPMA. The Journal of the Pakistan Medical Association [J Pak Med Assoc] 2019 Sep; Vol. 69 (9), pp. 1266-1272. - Publication Year :
- 2019
-
Abstract
- Purpose: Hodgkin lymphoma (HL) is one of the most curable paediatric cancers, with long-term survival rates now exceeding 90% after treatment with chemotherapy alone or combined with radiotherapy (RT). Treatment options for Hodgkin's Lymphoma differ among various study groups and there is still no consensus regarding the standard treatment for Hodgkin's lymphoma. Taking into account the impact of treatment-related mortality in low- and middle-income countries we propose to study the the clinical features and treatment outcomes by using different chemotherapy protocols in Hodgk in s' s Lymphoma children's at Shaukat khanam hospital Lahore..<br />Methods: Clinical data from a large regional cancer center Pediatrics patients with Hodgkin's Lymphoma from January 2009 till December 2015 was retrospectively collected after Institutional Review Board (IRB) approval.<br />Results: A total of 748 patients were reviewed retrospectively. Mostly (45%) were in 6-10 years age group. Male showed predominance ,male to female ratio was 4:1. B symptoms were present in 51%, bulky disease in 44% and ESR was more than 30mm in 26% of patients. CD 30 was positive in 95%, Bone marrow involved in 13% of patients. Stage I in 8%, stage- II in 27%, stage -III in 39% and stage IV in 26% was seen. COPDAc/ABVD was given in 412 patients, CHLVPP/ABVD in 176 patients, OEPA/COPP in 57 patients, OEPA in 35 patients, OEPA/COPDAC in 33 Patients and remaining 33 received various chemotherapy protocol combination. XRT was given in 17% of patients. Of these 86% of patients were alive ,5% patients died , 3% patients abandoned, 6% patients relapsed ,3% patients progressed while on chemotherapy. Five years Overall survival was 94% and 5 Years Event free survival was 91%. Minimum haematological and other toxicity was seen in patients who had received COPDac/ABVD when compared to other regimen.<br />Conclusions: Hodgkin's lymphoma patients had good outcome with different chemotherapy regimens, however our experience showed that the COPDac/ABVD regimen wass better tolerated with minimum toxicity.
- Subjects :
- Adolescent
Bleomycin therapeutic use
Child
Child, Preschool
Chlorambucil therapeutic use
Cyclophosphamide therapeutic use
Dacarbazine therapeutic use
Doxorubicin therapeutic use
Etoposide therapeutic use
Female
Hodgkin Disease pathology
Humans
Infant
Kaplan-Meier Estimate
Male
Neoplasm Staging
Pakistan
Prednisolone therapeutic use
Prednisone therapeutic use
Procarbazine therapeutic use
Prognosis
Radiotherapy, Adjuvant
Retrospective Studies
Survival Rate
Tertiary Care Centers
Treatment Outcome
Vinblastine therapeutic use
Vincristine therapeutic use
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Hodgkin Disease drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0030-9982
- Volume :
- 69
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- JPMA. The Journal of the Pakistan Medical Association
- Publication Type :
- Academic Journal
- Accession number :
- 31511710