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Case Report: Paracoccidioidomycosis in Solid Organ Transplantation: Disseminated Disease in a Liver Recipient and Literature Review.
- Source :
-
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2019 Nov; Vol. 101 (5), pp. 1100-1106. - Publication Year :
- 2019
-
Abstract
- Paracoccidioidomycosis (PCM) is an endemic systemic mycosis that is of great importance in Latin America. Its occurrence in solid organ transplantation (SOT) is rare, but with high mortality rate. In this report, we describe a case of PCM in a liver transplant recipient 19 months after transplantation. The patient presented with multiple skin abscesses, arthritis, osteolytic lesions, and pulmonary and adrenal involvement. Despite the presence of disseminated disease and the patient's immunosuppressed condition, the patient responded well to prolonged antifungal treatment with no sequelae, thus suggesting that early diagnosis and correct treatment may lead to favorable outcomes in SOT recipients with PCM.
- Subjects :
- Amphotericin B administration & dosage
Amphotericin B therapeutic use
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents therapeutic use
Antifungal Agents therapeutic use
Brazil epidemiology
Humans
Male
Middle Aged
Paracoccidioides
Paracoccidioidomycosis epidemiology
Trimethoprim, Sulfamethoxazole Drug Combination administration & dosage
Trimethoprim, Sulfamethoxazole Drug Combination therapeutic use
Liver Transplantation adverse effects
Paracoccidioidomycosis diagnosis
Paracoccidioidomycosis drug therapy
Transplant Recipients
Subjects
Details
- Language :
- English
- ISSN :
- 1476-1645
- Volume :
- 101
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The American journal of tropical medicine and hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 31516118
- Full Text :
- https://doi.org/10.4269/ajtmh.18-1008