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Immune checkpoint blockade in small cell lung cancer.
- Source :
-
Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2019 Nov; Vol. 137, pp. 31-37. Date of Electronic Publication: 2019 Aug 22. - Publication Year :
- 2019
-
Abstract
- Despite the highly immunogenic potential of small cell lung cancer (SCLC), progress in evaluating the therapeutic value of immune checkpoint agents has lagged behind that of non-small cell lung cancer. Results from a number of phase I-III clinical trials that specifically address the use of anti-PD-1, anti-PD-L1 and anti-CTLA-4 agents in SCLC have now been reported. This review will focus on the available evidence for immune checkpoint blockade in SCLC and review current biomarker strategies with the aim of providing perspective and interpretation of this data for clinical practice.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
B7-H1 Antigen immunology
CTLA-4 Antigen immunology
Humans
Lung Neoplasms immunology
Small Cell Lung Carcinoma immunology
Antineoplastic Agents, Immunological therapeutic use
B7-H1 Antigen antagonists & inhibitors
CTLA-4 Antigen antagonists & inhibitors
Immunotherapy methods
Lung Neoplasms drug therapy
Small Cell Lung Carcinoma drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8332
- Volume :
- 137
- Database :
- MEDLINE
- Journal :
- Lung cancer (Amsterdam, Netherlands)
- Publication Type :
- Academic Journal
- Accession number :
- 31525648
- Full Text :
- https://doi.org/10.1016/j.lungcan.2019.08.024