Synthetic Strategies for (-)-Cannabidiol and Its Structural Analogs.

Authors :: Jung B
Lee JK
Kim J
Kang EK
Han SY
Lee HY
Choi IS
Source :: Chemistry, an Asian journal [Chem Asian J] 2019 Nov 04; Vol. 14 (21), pp. 3749-3762. Date of Electronic Publication: 2019 Oct 08.
Publication Year :: 2019
Abstract: (-)-Cannabidiol ((-)-CBD), a non-psychoactive phytocannabinoid from Cannabis, and its structural analogs have received growing attention in recent years because of their potential therapeutic benefits, including neuroprotective, anti-epileptic, anti-inflammatory, anxiolytic, and anti-cancer properties. (-)-CBD and its analogs have been obtained mainly based on extraction from the natural source; however, the conventional extraction-based methods have some drawbacks, such as poor quality control along with purification difficulty. Chemical-synthetic strategies for (-)-CBD could tackle these issues, and, additionally, generate novel (-)-CBD analogs that exhibit advanced biological activities. This review concisely summarizes the historic and recent milestones in the synthetic strategies for (-)-CBD and its analogs.<br /> (© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)