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[Directed evolution in drug and antibody development : From the Nobel Prize to broad clinical application].

Authors :
Beck-Sickinger AG
Source :
Der Internist [Internist (Berl)] 2019 Oct; Vol. 60 (10), pp. 1014-1020.
Publication Year :
2019

Abstract

Combinatorial procedures have become established in recent years as alternatives to rational design in drug research, particularly when no structural information is available. This article presents the principle that was originally developed by three scientists and was honored with the Nobel Prize for Chemistry in 2018. Furthermore, the application in the field of monclonal antibodies is discussed.

Details

Language :
German
ISSN :
1432-1289
Volume :
60
Issue :
10
Database :
MEDLINE
Journal :
Der Internist
Publication Type :
Academic Journal
Accession number :
31541280
Full Text :
https://doi.org/10.1007/s00108-019-00675-1