PharmVar GeneFocus: CYP2D6.

Authors :: Nofziger C
Turner AJ
Sangkuhl K
Whirl-Carrillo M
Agúndez JAG
Black JL
Dunnenberger HM
Ruano G
Kennedy MA
Phillips MS
Hachad H
Klein TE
Gaedigk A
Source :: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2020 Jan; Vol. 107 (1), pp. 154-170. Date of Electronic Publication: 2019 Dec 09.
Publication Year :: 2020
Abstract: The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism of numerous drugs and, thus, can impact drug efficacy and safety. This GeneFocus provides a comprehensive overview and summary of CYP2D6 genetic variation and describes how the information provided by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC).<br /> (© 2019 The Authors Clinical Pharmacology & Therapeutics © 2019 American Society for Clinical Pharmacology and Therapeutics.)