Back to Search
Start Over
Endogenous n -3 Polyunsaturated Fatty Acids Are Beneficial to Dampen CD8 + T Cell-Mediated Inflammatory Response upon the Viral Infection in Mice.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2019 Sep 12; Vol. 20 (18). Date of Electronic Publication: 2019 Sep 12. - Publication Year :
- 2019
-
Abstract
- Omega-3 ( n -3) polyunsaturated fatty acids (PUFAs) have been known to exert anti-inflammatory effects on various disease states. However, its effect on CD8 <superscript>+</superscript> T cell-mediated immunopathology upon viral infection has not been well elucidated yet. In this study, we investigated the possible implication of n -3 PUFAs in CD8 <superscript>+</superscript> T cell responses against an acute viral infection. Infection of FAT-1 transgenic mice that are capable of synthesizing n -3 PUFAs from n -6 PUFAs with lymphocytic choriomeningitis virus (LCMV) resulted in significant reduction of anti-viral CD8 <superscript>+</superscript> T cell responses. Interestingly, expansion of adoptively transferred wild-type (WT) LCMV-specific T cell receptor (TCR) transgenic CD8 <superscript>+</superscript> (P14) T cells into FAT-1 mice was significantly decreased. Also, activation of anti-viral CD4 <superscript>+</superscript> helper T cells was reduced in FAT-1 mice. Importantly, P14 cells carrying the fat-1 gene that were adoptively transferred into WT mice exhibited a substantially decreased ability to proliferate and produce cytokines against LCMV infection. Together, n -3 PUFAs attenuated anti-viral CD8 <superscript>+</superscript> T cell responses against an acute viral infection and thus could be used to alleviate immunopathology mediated by the viral infection.
- Subjects :
- Animals
CD8-Positive T-Lymphocytes virology
Inflammation immunology
Inflammation virology
Lymphocytic Choriomeningitis immunology
Lymphocytic Choriomeningitis virology
Mice
Mice, Inbred C57BL
Mice, Transgenic
CD8-Positive T-Lymphocytes immunology
Fatty Acids, Omega-3 immunology
Inflammation etiology
Lymphocytic Choriomeningitis complications
Lymphocytic choriomeningitis virus immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 20
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 31547227
- Full Text :
- https://doi.org/10.3390/ijms20184510