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Perivascular Adipose Tissue Contributes to the Modulation of Vascular Tone in vivo.
- Source :
-
Journal of vascular research [J Vasc Res] 2019; Vol. 56 (6), pp. 320-332. Date of Electronic Publication: 2019 Sep 24. - Publication Year :
- 2019
-
Abstract
- Background: Perivascular adipose tissue (PVAT) reduces vascular tone in isolated arteries in vitro, however there are no studies of PVAT effects on vascular tone in vivo. In vitro adipocyte β3-adrenoceptors play a role in PVAT function via secretion of the vasodilator adiponectin.<br />Objective: We have investigated the effects of PVAT on vessel diameter in vivo, and the contributions of β3-adrenoceptors and adiponectin.<br />Method: In anaesthetised rats, sections of the intact mesenteric bed were visualised and the diameter of arteries was recorded. Arteries were stimulated with electrical field stimulation (EFS), noradrenaline (NA), arginine-vasopressin (AVP), and acetylcholine (Ach).<br />Results: We report that in vivo, stimulation of PVAT with EFS, NA, and AVP evokes a local anti-constrictive effect on the artery, whilst PVAT exerts a pro-contractile effect on arteries subjected to Ach. The anti-constrictive effect of PVAT stimulated with EFS and NA was significantly reduced using β3-adrenoceptor inhibition, and activation of β3-adrenoceptors potentiated the anti-constrictive effect of vessels stimulated with EFS, NA, and AVP. The β3-adrenoceptor agonist had no effect on mesenteric arteries with PVAT removed. A blocking peptide for adiponectin receptor 1 polyclonal antibody reduced the PVAT anti-constrictive effect in arteries stimulated with EFS and NA, indicating that adiponectin may be the anti-constrictive factor released upon β3-adrenoceptor activation.<br />Conclusions: These results clearly demonstrate that PVAT plays a paracrine role in regulating local vascular tone in vivo, and therefore may contribute to the modulation of blood pressure. This effect is mediated via adipocyte β3-adrenoceptors, which may trigger release of the vasodilator adiponectin.<br /> (© 2019 S. Karger AG, Basel.)
- Subjects :
- Adipose Tissue drug effects
Adrenergic beta-3 Receptor Agonists pharmacology
Adrenergic beta-3 Receptor Antagonists pharmacology
Animals
Electric Stimulation
Male
Mesenteric Arteries drug effects
Rats, Wistar
Receptors, Adrenergic, beta-3 drug effects
Signal Transduction
Vasoconstrictor Agents pharmacology
Vasodilator Agents pharmacology
Adiponectin metabolism
Adipose Tissue metabolism
Mesenteric Arteries metabolism
Paracrine Communication drug effects
Receptors, Adrenergic, beta-3 metabolism
Vasoconstriction drug effects
Vasodilation drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0135
- Volume :
- 56
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of vascular research
- Publication Type :
- Academic Journal
- Accession number :
- 31550717
- Full Text :
- https://doi.org/10.1159/000502689