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Visual sensory processing is altered in myoclonus dystonia.

Authors :
Tarrano C
Wattiez N
Delorme C
McGovern EM
Brochard V
Thobois S
Tranchant C
Grabli D
Degos B
Corvol JC
Pedespan JM
Krystkoviak P
Houeto JL
Degardin A
Defebvre L
Valabrègue R
Vidailhet M
Pouget P
Roze E
Worbe Y
Source :
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2020 Jan; Vol. 35 (1), pp. 151-160. Date of Electronic Publication: 2019 Sep 30.
Publication Year :
2020

Abstract

Background: Abnormal sensory processing, including temporal discrimination threshold, has been described in various dystonic syndromes.<br />Objective: To investigate visual sensory processing in DYT-SGCE and identify its structural correlates.<br />Methods: DYT-SGCE patients without DBS (DYT-SGCE-non-DBS) and with DBS (DYT-SGCE-DBS) were compared to healthy volunteers in three tasks: a temporal discrimination threshold, a movement orientation discrimination, and movement speed discrimination. Response times attributed to accumulation of sensory visual information were computationally modelized, with μ parameter indicating sensory mean growth rate. We also identified the structural correlates of behavioral performance for temporal discrimination threshold.<br />Results: Twenty-four DYT-SGCE-non-DBS, 13 DYT-SGCE-DBS, and 25 healthy volunteers were included in the study. In DYT-SGCE-DBS, the discrimination threshold was higher in the temporal discrimination threshold (P = 0.024), with no difference among the groups in other tasks. The sensory mean growth rate (μ) was lower in DYT-SGCE in all three tasks (P < 0.01), reflecting a slower rate of sensory accumulation for the visual information in these patients independent of DBS. Structural imaging analysis showed a thicker left primary visual cortex (P = 0.001) in DYT-SGCE-non-DBS compared to healthy volunteers, which also correlated with lower μ in temporal discrimination threshold (P = 0.029). In DYT-SGCE-non-DBS, myoclonus severity also correlated with a lower μ in the temporal discrimination threshold task (P = 0.048) and with thicker V1 on the left (P = 0.022).<br />Conclusion: In DYT-SGCE, we showed an alteration of the visual sensory processing in the temporal discrimination threshold that correlated with myoclonus severity and structural changes in the primary visual cortex. © 2019 International Parkinson and Movement Disorder Society.<br /> (© 2019 International Parkinson and Movement Disorder Society.)

Details

Language :
English
ISSN :
1531-8257
Volume :
35
Issue :
1
Database :
MEDLINE
Journal :
Movement disorders : official journal of the Movement Disorder Society
Publication Type :
Academic Journal
Accession number :
31571302
Full Text :
https://doi.org/10.1002/mds.27857