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Cardiotoxicity of Immune Therapy.

Authors :
Ganatra S
Parikh R
Neilan TG
Source :
Cardiology clinics [Cardiol Clin] 2019 Nov; Vol. 37 (4), pp. 385-397. Date of Electronic Publication: 2019 Aug 27.
Publication Year :
2019

Abstract

The advent of immunotherapy, particularly immune checkpoint inhibitors and chimeric antigen receptor T-cell therapy, has ushered in a promising new era of treatment of patients with a variety of malignancies who historically had a poor prognosis. However, these therapies are associated with potentially life-threatening cardiovascular adverse effects. As immunotherapy evolves to include a wider variety of malignancies, risk stratification, prompt recognition, and treatment of cardiotoxicity will become increasingly important and hence cardiologists will need to play a fundamental role in the comprehensive care of these patients. This article reviews cardiotoxicity associated with contemporary immunotherapy and discusses potential management strategies.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1558-2264
Volume :
37
Issue :
4
Database :
MEDLINE
Journal :
Cardiology clinics
Publication Type :
Academic Journal
Accession number :
31587780
Full Text :
https://doi.org/10.1016/j.ccl.2019.07.008