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Physiological significance of ghrelin in the cardiovascular system.
- Source :
-
Proceedings of the Japan Academy. Series B, Physical and biological sciences [Proc Jpn Acad Ser B Phys Biol Sci] 2019; Vol. 95 (8), pp. 459-467. - Publication Year :
- 2019
-
Abstract
- Ghrelin, a growth hormone-releasing peptide first discovered in rat stomach in 1999, is a ligand for the growth hormone secretagogue receptor. It participates in the regulation of diverse processes, including energy balance and body weight maintenance, and appears to be beneficial for the treatment of cardiovascular diseases. In animal models of chronic heart failure, ghrelin improves cardiac function and remodeling; these findings have been recapitulated in human patients. In other animal models, ghrelin effectively diminishes pulmonary hypertension. Moreover, ghrelin administration early after myocardial infarction decreased the frequency of fatal arrhythmia and improved survival rate. In ghrelin-deficient mice, endogenous ghrelin protects against fatal arrhythmia and promotes remodeling after myocardial infarction. Although the mechanisms underlying the effects of ghrelin on the cardiovascular system have not been fully elucidated, its beneficial effects appear to be mediated through regulation of the autonomic nervous system. Ghrelin is a promising therapeutic agent for cardiac diseases.
- Subjects :
- Amino Acid Sequence
Animals
Autonomic Nervous System metabolism
Autonomic Nervous System physiology
Cardiovascular System drug effects
Cardiovascular System physiopathology
Ghrelin chemistry
Ghrelin pharmacology
Ghrelin therapeutic use
Heart Diseases drug therapy
Heart Diseases physiopathology
Humans
Receptors, Ghrelin metabolism
Cardiovascular System metabolism
Ghrelin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1349-2896
- Volume :
- 95
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Proceedings of the Japan Academy. Series B, Physical and biological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 31611501
- Full Text :
- https://doi.org/10.2183/pjab.95.032