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Exogenous brain-derived neurotrophic factor attenuates neuronal apoptosis and neurological deficits after subarachnoid hemorrhage in rats.
- Source :
-
Experimental and therapeutic medicine [Exp Ther Med] 2019 Nov; Vol. 18 (5), pp. 3837-3844. Date of Electronic Publication: 2019 Sep 19. - Publication Year :
- 2019
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Abstract
- Brain-derived neurotrophic factor (BDNF) is a growth factor crucial for neuronal survival, while its role in subarachnoid hemorrhage (SAH)-induced neuronal apoptosis remains unclear. The aim of the present study was to investigate whether administering exogenous BDNF can protect against neuronal apoptosis and neurological deficits following SAH in a rat model. The BDNF level was found to be significantly decreased in the basal cortex at 6, 12, 24, 48 and 72 h following SAH. Exogenous BDNF significantly decreased the expression of Bax and reduced activation of caspase-3 and caspase-9 and the number of apoptotic neurons. Moreover, exogenous BDNF treatment significantly improved the neurological deficits at 72 h and long-term behavioral deficits (day 14) following SAH in a rat model. These findings indicate that exogenous BDNF attenuated SAH-induced neuronal injury in rats.<br /> (Copyright: © Chen et al.)
Details
- Language :
- English
- ISSN :
- 1792-0981
- Volume :
- 18
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Experimental and therapeutic medicine
- Publication Type :
- Academic Journal
- Accession number :
- 31616511
- Full Text :
- https://doi.org/10.3892/etm.2019.8029