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Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2019 Oct 31; Vol. 55 (88), pp. 13267-13270. - Publication Year :
- 2019
-
Abstract
- Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.
- Subjects :
- Antineoplastic Agents pharmacology
Cell Death drug effects
Cell Line, Tumor
Cell Proliferation drug effects
Cell Survival drug effects
Drug Screening Assays, Antitumor
Fluorescent Dyes pharmacology
Humans
Male
Models, Molecular
Molecular Structure
Monoamine Oxidase metabolism
Monoamine Oxidase Inhibitors pharmacology
Optical Imaging
Photons
Prostatic Neoplasms drug therapy
Prostatic Neoplasms metabolism
Antineoplastic Agents chemistry
Fluorescent Dyes chemistry
Monoamine Oxidase analysis
Monoamine Oxidase Inhibitors chemistry
Prostatic Neoplasms diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 55
- Issue :
- 88
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 31621760
- Full Text :
- https://doi.org/10.1039/c9cc07009e