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Radiotherapy can increase the risk of ischemic cerebrovascular disease in head and neck cancer patients: A Korean population-based cohort study.
- Source :
-
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2020 Jan; Vol. 142, pp. 85-91. Date of Electronic Publication: 2019 Oct 17. - Publication Year :
- 2020
-
Abstract
- Background and Purpose: Several reports suggested that radiotherapy (RT) was related to an increased risk of cerebrovascular disease (CVD) in head and neck cancer (HNC) patients, but other risk factors of CVD were not properly considered in estimating the risk of RT. The purpose of this study is to analyze the effect of RT on the risk of CVD in HNC patients.<br />Materials and Methods: The Korean Central Cancer Registry data and Korean National Health Insurance Service data were used. A total of 5570 patients with newly diagnosed HNC between the years 2003-2005 was included in our study cohort. We analyzed the effect of treatment modality and other socioeconomic variables on ischemic CVD incidence using the Cox proportional hazard regression model both in the entire cohort (n = 5570) and in the propensity score matching (PSM) cohort (n = 3310).<br />Results: RT increased the CVD risk by 40.8% (aHR: 1.408, p = 0.006) in the entire cohort and by 44.3% (aHR: 1.443, p = 0.047) in the PSM cohort, respectively.<br />Conclusion: The risk of ischemic CVD increased by RT after adjusting for other socioeconomic and clinical risk factors. Regular follow up and appropriate screening for CVD are required for HNC patients who received RT, and focus should be on advanced-age patients with a low socioeconomic status and known clinical risk factors of CVD.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Aged
Cerebrovascular Disorders etiology
Cohort Studies
Female
Head and Neck Neoplasms epidemiology
Humans
Incidence
Ischemia epidemiology
Ischemia etiology
Male
Middle Aged
Proportional Hazards Models
Radiation Injuries etiology
Radiotherapy adverse effects
Radiotherapy statistics & numerical data
Registries
Republic of Korea epidemiology
Risk Factors
Squamous Cell Carcinoma of Head and Neck epidemiology
Cerebrovascular Disorders epidemiology
Head and Neck Neoplasms radiotherapy
Radiation Injuries epidemiology
Squamous Cell Carcinoma of Head and Neck radiotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0887
- Volume :
- 142
- Database :
- MEDLINE
- Journal :
- Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 31630865
- Full Text :
- https://doi.org/10.1016/j.radonc.2019.09.025