Back to Search
Start Over
Systemic sclerosis patients are at higher risk of hyperthyroidism and have a worse survival than those without hyperthyroidism: A nationwide population-based cohort study.
- Source :
-
European journal of clinical investigation [Eur J Clin Invest] 2019 Dec; Vol. 49 (12), pp. e13177. Date of Electronic Publication: 2019 Nov 25. - Publication Year :
- 2019
-
Abstract
- Background: A high prevalence of thyroid disorders has been reported in patients with autoimmune diseases. The link between hyperthyroidism and systemic sclerosis (SSc) has been relatively overlooked, and only a few studies utilizing small samples or case reports have been reported so far.<br />Objectives: To investigate the association between SSc and hyperthyroidism.<br />Methods: We designed a case-control study utilizing the medical database of the Clalit Health Services. Chi-square and t tests were used for univariate analysis, and a logistic regression model was used for multivariate analysis.<br />Results: The study included 2,431 SSc patients and 12,710 age- and sex-matched controls. The mean age of the study population was 63.32 ± 18.06 years (median 66 years), and female-to-male ratio was 4.5:1. Age (P < .0001, OR 1.03 [95% CI 1.02-1.04]), female sex (P = .0015, OR 1.86 [95% CI 1.27- 2.74]) and diagnosis of SSc (P = .0011, OR 1.81[95% CI 1.27-2.58]) were all independently associated with hyperthyroidism. Patients with SSc and hyperthyroidism had 1.54-fold increase of mortality rates during a mean follow-up of 17 years than SSc patients without hyperthyroidism, even though at the Cox multivariate survival analysis, only age (HR 1.06 [95% CI 1.06-1.07], P < .0001) and diagnosis of SSc (HR 2.35 [CI 2.06 to 2.69], P < .0001) resulted associated with a higher risk of mortality.<br />Conclusions: Hyperthyroidism is highly prevalent among SSc patients and can negatively impact on their survival rates. Therefore, a pre-emptive screening may be warranted in all SSc patients. Further studies are needed to evaluate whether tight control and optimal treatment for hyperthyroidism may lead to a reduction of all-cause mortality in patients with SSc.<br /> (© 2019 Stichting European Society for Clinical Investigation Journal Foundation.)
- Subjects :
- Age Factors
Aged
Aged, 80 and over
Case-Control Studies
Cohort Studies
Comorbidity
Female
Humans
Israel epidemiology
Logistic Models
Male
Middle Aged
Multivariate Analysis
Prevalence
Proportional Hazards Models
Survival Analysis
Hyperthyroidism epidemiology
Scleroderma, Systemic epidemiology
Survival Rate
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2362
- Volume :
- 49
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- European journal of clinical investigation
- Publication Type :
- Academic Journal
- Accession number :
- 31633804
- Full Text :
- https://doi.org/10.1111/eci.13177