Recent advance of erythrocyte-mimicking nanovehicles: From bench to bedside.

Authors :: Yang J
Wang F
Lu Y
Qi J
Deng L
Sousa F
Sarmento B
Xu X
Cui W
Source :: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2019 Nov 28; Vol. 314, pp. 81-91. Date of Electronic Publication: 2019 Oct 20.
Publication Year :: 2019
Abstract: Erythrocyte-mimicking nanovehicles (EM-NVs) are developed by fusing nanoparticle cores with naturally derived erythrocyte membranes. Compared with conventional nanosystems, EM-NVs hold preferable characteristics of prolonged blood circulation time and immune evasion. Due to the cell surface mimetic properties, along with tailored core material, EM-NVs have huge application potential in a large variety of biomedical fields, which are anticipated to revolutionize the present theranostic modalities of diseases in clinic. This review focuses on (I) drug carriers, (II) photosensitizers, (III) antidotes, (IV) vaccines and (V) probes, aiming to present an overall summary of the latest advancement in the application of EM-NVs, and highlight the major challenges and opportunities in this field.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)

Subjects :: Animals
Drug Carriers chemistry
Erythrocyte Membrane chemistry
Humans
Surface Properties
Theranostic Nanomedicine methods
Biomimetic Materials chemistry
Erythrocytes chemistry
Nanoparticles

Language :: English
ISSN :: 1873-4995
Volume :: 314
Database :: MEDLINE
Journal :: Journal of controlled release : official journal of the Controlled Release Society
Publication Type :: Academic Journal
Accession number :: 31644936
Full Text :: https://doi.org/10.1016/j.jconrel.2019.10.032