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MRI-based visualization of rTMS-induced cortical plasticity in the primary motor cortex.
- Source :
-
PloS one [PLoS One] 2019 Oct 24; Vol. 14 (10), pp. e0224175. Date of Electronic Publication: 2019 Oct 24 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Repetitive transcranial magnetic stimulation (rTMS) induces changes in cortical excitability for minutes to hours after the end of intervention. However, it has not been precisely determined to what extent cortical plasticity prevails spatially in the cortex. Recent studies have shown that rTMS induces changes in "interhemispheric" functional connectivity, the resting-state functional connectivity between the stimulated region and the symmetrically corresponding region in the contralateral hemisphere. In the present study, quadripulse stimulation (QPS) was applied to the index finger representation in the left primary motor cortex (M1), while the position of the stimulation coil was constantly monitored by an online navigator. After QPS application, resting-state functional magnetic resonance imaging was performed, and the interhemispheric functional connectivity was compared with that before QPS. A cluster of connectivity changes was observed in the stimulated region in the central sulcus. The cluster was spatially extended approximately 10 mm from the center [half width at half maximum (HWHM): approximately 3 mm] and was extended approximately 20 mm long in depth (HWHM: approximately 7 mm). A localizer scan of the index finger motion confirmed that the cluster of interhemispheric connectivity changes overlapped spatially with the activation related to the index finger motion. These results indicate that cortical plasticity in M1 induced by rTMS was relatively restricted in space and suggest that rTMS can reveal functional dissociation associated with adjacent small areas by inducing neural plasticity in restricted cortical regions.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Adult
Brain radiation effects
Female
Functional Laterality
Humans
Male
Middle Aged
Motor Cortex radiation effects
Neuronal Plasticity radiation effects
Young Adult
Brain physiology
Evoked Potentials, Motor physiology
Magnetic Resonance Imaging methods
Motor Cortex physiology
Neuronal Plasticity physiology
Transcranial Magnetic Stimulation methods
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 14
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 31648225
- Full Text :
- https://doi.org/10.1371/journal.pone.0224175