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Preliminary assessment of serum clusterin as a potential biomarker for canine lymphoma.
- Source :
-
Veterinary and comparative oncology [Vet Comp Oncol] 2020 Sep; Vol. 18 (3), pp. 292-302. Date of Electronic Publication: 2019 Nov 14. - Publication Year :
- 2020
-
Abstract
- Clusterin (CLU), also known as apolipoprotein J, is a widely expressed, heterodimeric, glycoprotein, important in tumourigenesis, apoptosis and immunoregulation. In humans, CLU expression has been associated with anaplastic large cell and Hodgkin's lymphoma. In this study, serum CLU levels in dogs with multicentric lymphoma (MLSA) were compared with healthy control dogs, using both western blot and enzyme-linked immunosorbent assay (ELISA). Western blot confirmed the presence of CLU in dog sera at the predicted molecular weight and the relative levels detected correlated with the levels detected by ELISA. CLU level analysis by ELISA found treatment naïve dogs with MLSA had a significantly (P < .001) lower serum CLU level compared with healthy controls. However, there was no significant difference between MLSA dogs prior to treatment and in complete remission. The wide variation in serum CLU levels may limit its potential as a single candidate biomarker for MLSA, although any prognostic predictive value of serum CLU concentrations has yet to be assessed.<br /> (© 2019 John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 1476-5829
- Volume :
- 18
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Veterinary and comparative oncology
- Publication Type :
- Academic Journal
- Accession number :
- 31654603
- Full Text :
- https://doi.org/10.1111/vco.12550