Back to Search
Start Over
Biocompatible co-loading vehicles for delivering both nanoplatin cores and siRNA to treat hepatocellular carcinoma.
- Source :
-
International journal of pharmaceutics [Int J Pharm] 2019 Dec 15; Vol. 572, pp. 118769. Date of Electronic Publication: 2019 Oct 26. - Publication Year :
- 2019
-
Abstract
- Bmi-1 is a gene related to malignant transformation in hepatocellular carcinoma (HCC). The liver cancer cells developed the ability to tolerate CDDP treatment with the elevation of Bmi-1. Bmi-1 is also an oncogene promoting malignance of tumor and an anti-cancer target in many studies. Herein, a biocompatible nanocarrier was designed in the study to deliver a chemotherapeutical agent CDDP and Bmi-1 siRNA to kill cancer cells and silence drug resistance related gene simultaneously. Calciumphosphate (CaP) was applied to coat both nanoplatin cores and siRNA as a shell for the purpose of delivering cargos to the cytosol of the tumor cells. Nanoplatin and siRNA co-loaded CaP nanoparticles (NPSC) enhanced cell uptake of CDDP and showed elevated drug accumulation in tumor. NPSC achieved considerable anti-cancer efficacy and counter-regulated drug tolerance, therefore, warranted a further investigation as a novel therapeutic nanosystem to improve cancer therapy.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Antineoplastic Agents pharmacology
Calcium Phosphates chemistry
Carcinoma, Hepatocellular genetics
Cell Line, Tumor
Drug Resistance, Neoplasm drug effects
Female
Hep G2 Cells
Humans
Liver Neoplasms genetics
Mice
Mice, Inbred BALB C
Mice, Nude
Polycomb Repressive Complex 1 genetics
Antineoplastic Agents chemistry
Biocompatible Materials chemistry
Carcinoma, Hepatocellular drug therapy
Liver Neoplasms drug therapy
Nanoparticles chemistry
RNA, Small Interfering chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3476
- Volume :
- 572
- Database :
- MEDLINE
- Journal :
- International journal of pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 31669557
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2019.118769