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Enterochromaffin cell hyperplasia in the gut: Factors, mechanism and therapeutic clues.
- Source :
-
Life sciences [Life Sci] 2019 Dec 15; Vol. 239, pp. 116886. Date of Electronic Publication: 2019 Oct 31. - Publication Year :
- 2019
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Abstract
- Enterochromaffin (EC) cell is the main cell type that responsible for 5-hydroxytryptamine (5-HT) synthesis, storage and release of the gut. Intestinal 5-HT play a key role in visceral sensation, intestinal motility and permeability, EC cell hyperplasia and increased 5-HT bioavailability in the gut have been found to be involved in the symptoms generation of irritable bowel syndrome and inflammatory bowel disease. EC cells originate from intestinal stem cells, the interaction between proliferation and differentiation signals on intestinal stem cells enable EC cell number to be regulated in a normal level. This review focuses on the impact factors, pathogenesis mechanisms, and therapeutic clues for intestinal EC cells hyperplasia, and showed that EC cell hyperplasia was observed under the condition of physiological stress, intestinal infection or intestinal inflammation, the disordered proliferation and/or differentiation of intestinal stem cells as well as their progenitor cells all contribute to the pathogenesis of intestinal EC cell hyperplasia. The altered intestinal niche, i.e. increased corticotrophin releasing factor (CRF) signal, elevated nerve growth factor (NGF) signal, and Th2-dominant cytokines production, has been found to have close correlation with intestinal EC cell hyperplasia. Currently, CRF receptor antagonist, nuclear factor-κB inhibitor, and NGF receptor neutralizing antibody have been proved useful to attenuate intestinal EC cell hyperplasia, which may provide a promising clue for the therapeutic strategy in EC cell hyperplasia related diseases.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Colon metabolism
Humans
Hyperplasia metabolism
Infections metabolism
Inflammation metabolism
Intestines pathology
Irritable Bowel Syndrome metabolism
Serotonin metabolism
Stress, Physiological physiology
Enterochromaffin Cells metabolism
Enterochromaffin Cells physiology
Hyperplasia pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0631
- Volume :
- 239
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 31678286
- Full Text :
- https://doi.org/10.1016/j.lfs.2019.116886