Back to Search
Start Over
A single coadministration of subeffective doses of ascorbic acid and ketamine reverses the depressive-like behavior induced by chronic unpredictable stress in mice.
- Source :
-
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2019 Dec; Vol. 187, pp. 172800. Date of Electronic Publication: 2019 Nov 01. - Publication Year :
- 2019
-
Abstract
- In this study, we investigated the ability of a single coadministration of subeffective doses of ascorbic acid and ketamine to reverse the depressive-like behavior induced by chronic unpredictable stress (CUS) in mice. Moreover, we examined the effect of combined administration of ascorbic acid and ketamine on hippocampal phosphorylation of p70S6K and immunocontents of GLUA1 and PSD-95 in mice submitted to the CUS procedure. CUS procedure was applied for 21 days. Animals received a single coadministration of subeffective doses of ascorbic acid (0.1 mg/kg) and ketamine (0.1 mg/kg) and were subjected to behavioral evaluation 24 h after the treatments. Immediately after the behavioral observations the hippocampi were dissected for Western blotting analyses. Our results revealed that a single administration of subeffective doses of ascorbic acid and ketamine completely reversed the depressive-like behavior induced by CUS, however, this effect was not accompanied by changes in the phosphorylation of p70S6K and immunocontent of GLUA1 or PSD95 in the hippocampus. These findings point to a synergistic antidepressant-like effect of ascorbic acid and ketamine, paving the way for additional studies on the combined use of these compounds for the management of major depressive disorder (MDD).<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Antidepressive Agents administration & dosage
Ascorbic Acid administration & dosage
Behavior, Animal drug effects
Depressive Disorder, Major drug therapy
Disease Models, Animal
Drug Synergism
Drug Therapy, Combination
Female
Hindlimb Suspension
Hippocampus drug effects
Ketamine administration & dosage
Locomotion drug effects
Mice
Treatment Outcome
Antidepressive Agents pharmacology
Ascorbic Acid pharmacology
Depression drug therapy
Depression etiology
Ketamine pharmacology
Stress, Psychological complications
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5177
- Volume :
- 187
- Database :
- MEDLINE
- Journal :
- Pharmacology, biochemistry, and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 31678791
- Full Text :
- https://doi.org/10.1016/j.pbb.2019.172800