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Alzheimer's disease risk SNPs show no strong effect on miRNA expression in human lymphoblastoid cell lines.

Authors :
Wohlers I
Schulz C
Kilpert F
Bertram L
Source :
Neurobiology of aging [Neurobiol Aging] 2020 Feb; Vol. 86, pp. 202.e1-202.e3. Date of Electronic Publication: 2019 Aug 20.
Publication Year :
2020

Abstract

The role of microRNAs (miRNAs) in the pathogenesis of Alzheimer's disease (AD) is currently extensively investigated. In this study, we assessed the potential impact of AD genetic risk variants on miRNA expression by performing large-scale bioinformatic data integration. Our analysis was based on genetic variants from 3 AD genome-wide association studies (GWASs). Association with miRNA expression was tested by expression quantitative trait locus analysis using next-generation miRNA sequencing data generated in lymphoblastoid cell lines. Although, overall, we did not identify a strong effect of AD GWAS variants on miRNA expression in this cell type, we highlight 2 notable outliers, that is, miR-29c-5p and miR-6840-5p. MiR-29c-5p was recently reported to be involved in the regulation of BACE1 and SORL1 expression. In conclusion, despite 2 exceptions, our large-scale assessment provides only limited support for the hypothesis that AD GWAS variants act as miRNA expression quantitative trait loci.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1558-1497
Volume :
86
Database :
MEDLINE
Journal :
Neurobiology of aging
Publication Type :
Academic Journal
Accession number :
31685236
Full Text :
https://doi.org/10.1016/j.neurobiolaging.2019.08.013