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Higher-Order Chromosomal Structures Mediate Genome Function.

Authors :
Jerković I
Szabo Q
Bantignies F
Cavalli G
Source :
Journal of molecular biology [J Mol Biol] 2020 Feb 07; Vol. 432 (3), pp. 676-681. Date of Electronic Publication: 2019 Nov 02.
Publication Year :
2020

Abstract

How chromosomes are organized within the tridimensional space of the nucleus and how can this organization affect genome function have been long-standing questions on the path to understanding genome activity and its link to disease. In the last decade, high-throughput chromosome conformation capture techniques, such as Hi-C, have facilitated the discovery of new principles of genome folding. Chromosomes are folded in multiple high-order structures, with local contacts between enhancers and promoters, intermediate-level contacts forming Topologically Associating Domains (TADs) and higher-order chromatin structures sequestering chromatin into active and repressive compartments. However, despite the increasing evidence that genome organization can influence its function, we are still far from understanding the underlying mechanisms. Deciphering these mechanisms represents a major challenge for the future, which large, international initiatives, such as 4DN, HCA and LifeTime, aim to collaboratively tackle by using a conjunction of state-of-the-art population-based and single-cell approaches.<br /> (Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Details

Language :
English
ISSN :
1089-8638
Volume :
432
Issue :
3
Database :
MEDLINE
Journal :
Journal of molecular biology
Publication Type :
Academic Journal
Accession number :
31689436
Full Text :
https://doi.org/10.1016/j.jmb.2019.10.014