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Peak width of skeletonized mean diffusivity and its association with age-related cognitive alterations and vascular risk factors.
- Source :
-
Alzheimer's & dementia (Amsterdam, Netherlands) [Alzheimers Dement (Amst)] 2019 Oct 25; Vol. 11, pp. 721-729. Date of Electronic Publication: 2019 Oct 25 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Introduction: Only two studies investigated the associations between peak width of skeletonized mean diffusivity (PSMD) and age-related cognitive alterations, whereas none of the studies investigated the association with vascular risk factors.<br />Methods: We evaluated 801 stroke- and dementia-free elderlies with baseline and 3-year follow-up assessments. Regression analyses were used to assess the association between age-related cognitive functions and PSMD. Simple mediation models were used to study the mediation effect of PSMD between vascular risk factors and age-related cognitive outcomes.<br />Results: PSMD was negatively associated with processing speed at baseline and negatively associated with processing and memory scores at 3-year follow-up. The association between vascular risk factors and age-related cognition was mediated by PSMD, as well as other diffusion tensor imaging markers.<br />Discussion: PSMD is preferred over other diffusion tensor imaging markers as it is sensitive to age-related cognitive alterations and calculation is fully automated. PSMD is proposed as a research tool to monitor age-related cognitive alterations.<br /> (© 2019 The Authors.)
Details
- Language :
- English
- ISSN :
- 2352-8729
- Volume :
- 11
- Database :
- MEDLINE
- Journal :
- Alzheimer's & dementia (Amsterdam, Netherlands)
- Publication Type :
- Academic Journal
- Accession number :
- 31700990
- Full Text :
- https://doi.org/10.1016/j.dadm.2019.09.003