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Alpha 1-adrenergic-induced airway obstruction in ponies with recurrent pulmonary disease.
- Source :
-
Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 1988 Aug; Vol. 65 (2), pp. 687-92. - Publication Year :
- 1988
-
Abstract
- We examined the response of five ponies with recurrent airway obstruction (principals) and five age- and gender-matched controls to the aerosol alpha-adrenergic agonist phenylephrine after blockade with propranolol and atropine. Measurements were made with principal ponies in clinical remission (period A) and during acute airway obstruction (period B). The blockade had no effect on base-line pulmonary mechanics in control ponies during periods A and B or in the principal ponies during period A. However, in the principal ponies during period B, blockade increased dynamic compliance (Cdyn) and decreased pulmonary resistance (RL). Phenylephrine had no effect on the controls during either period. In the principals, phenylephrine decreased Cdyn and increased RL during both periods. The alpha 1-agonist aerosol prazosin shifted the phenylephrine dose-response curves to the right, but prasozin did not bronchodilate the principals during period B. This suggests that the role of alpha 1-adrenergic receptors in airway narrowing in ponies with recurrent airway obstruction is minimal. However, the response to phenylephrine in only the principal ponies suggests an increase in alpha-receptor numbers and/or activity in these animals compared with controls.
- Subjects :
- Airway Obstruction physiopathology
Animals
Atropine pharmacology
Dose-Response Relationship, Drug
Female
Horses
Male
Phenylephrine antagonists & inhibitors
Prazosin pharmacology
Propranolol pharmacology
Airway Obstruction veterinary
Airway Resistance drug effects
Horse Diseases physiopathology
Lung Compliance drug effects
Phenylephrine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 8750-7587
- Volume :
- 65
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of applied physiology (Bethesda, Md. : 1985)
- Publication Type :
- Academic Journal
- Accession number :
- 3170423
- Full Text :
- https://doi.org/10.1152/jappl.1988.65.2.687