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Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction.
- Source :
-
JACC. Basic to translational science [JACC Basic Transl Sci] 2019 Oct 28; Vol. 4 (6), pp. 701-714. Date of Electronic Publication: 2019 Oct 28 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- No effective treatment is yet available to reduce infarct size and improve clinical outcomes after acute myocardial infarction by enhancing early reperfusion therapy using primary percutaneous coronary intervention. The study showed that Kyoto University Substance 121 (KUS121) reduced endoplasmic reticulum stress, maintained adenosine triphosphate levels, and ameliorated the infarct size in a murine cardiac ischemia and reperfusion injury model. The study confirmed the cardioprotective effect of KUS121 in a porcine ischemia and reperfusion injury model. These findings confirmed that KUS121 is a promising novel therapeutic agent for myocardial infarction in conjunction with primary percutaneous coronary intervention.<br /> (© 2019 The Authors.)
Details
- Language :
- English
- ISSN :
- 2452-302X
- Volume :
- 4
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- JACC. Basic to translational science
- Publication Type :
- Academic Journal
- Accession number :
- 31709319
- Full Text :
- https://doi.org/10.1016/j.jacbts.2019.06.001