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Patch Testing With Formaldehyde 2.0% (0.60 mg/cm2) Detects More Contact Allergy to Formaldehyde Than 1.0.
- Source :
-
Dermatitis : contact, atopic, occupational, drug [Dermatitis] 2019 Nov/Dec; Vol. 30 (6), pp. 342-346. - Publication Year :
- 2019
-
Abstract
- Background: The International Contact Dermatitis Research Group increased the patch test concentration of formaldehyde from 1.0% aqueous (aq) to 2.0% aq (in 2011).<br />Objective: This study was designed to investigate the outcome of the decision.<br />Methods: Consecutive dermatitis patients in 8 different clinics were patch tested with formaldehyde 1.0% aq and 2.0% aq. The test solutions were applied with a micropipette to the filter paper discs in the respective chamber.<br />Results: A total of 2778 patients were tested with 1.0% aq and 2766 to 2.0% aq. Sixty-five patients (2.3%, calculated from 2766 tested, to 2.0% aq) had positive patch test reactions interpreted as contact allergy to formaldehyde. This is a rather low frequency. Of these 65, 46 were women (46/1703 [2.7%]) and 19 were men (19/1063 [1.8%]). Thirty-six reacted only to 2.0% aq, 21 patients reacted to both concentrations, and 8 patients reacted only to 1.0% aq. Significantly, more patients reacted to 2.0% aq compared with 1.0% aq (P < 0.001). There was no significant sex difference. A total of 0.8% irritant reactions were recorded to formaldehyde 2.0% aq and 0.1% to 1.0% aq.<br />Conclusions: The increased formaldehyde patch test concentration to 2.0% aq revealed more formaldehyde contact allergy.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Dermatitis, Allergic Contact epidemiology
Dermatitis, Allergic Contact etiology
Female
Humans
Male
Middle Aged
Young Adult
Dermatitis, Allergic Contact diagnosis
Disinfectants adverse effects
Formaldehyde adverse effects
Patch Tests methods
Subjects
Details
- Language :
- English
- ISSN :
- 2162-5220
- Volume :
- 30
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Dermatitis : contact, atopic, occupational, drug
- Publication Type :
- Academic Journal
- Accession number :
- 31730552
- Full Text :
- https://doi.org/10.1097/DER.0000000000000510