Photodynamic therapy inhibits cell growth and enhances the histone deacetylase-mediated viability impairment in Cryptococcus spp. in vitro.

Authors :: Morais JAV
Rodrigues MC
Ferreira FF
Ranjan K
Azevedo RB
Poças-Fonseca MJ
Muehlmann LA
Source :: Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2020 Mar; Vol. 29, pp. 101583. Date of Electronic Publication: 2019 Nov 12.
Publication Year :: 2020
Abstract: Cryptococcosis is a disseminated infection caused mainly by C. neoformans and C. gattii. Limitations for the treatment involve the selection of isolates resistant to conventional antifungal drugs, prolonged treatment time and drugs side effects. This study evaluated the combined effect of histone deacetylase inhibitors (HDACi) and photodynamic therapy (PDT) on the growth of C. neoformans and C. gattii in vitro. Results showed that PDT inhibited yeasts proliferation and enhanced the HDACi-mediated cell viability impairment in Cryptococcus spp.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)

Subjects :: Cell Cycle drug effects
Humans
Cryptococcus drug effects
Histone Deacetylase Inhibitors pharmacology
Indoles pharmacology
Organometallic Compounds pharmacology
Photochemotherapy methods
Photosensitizing Agents pharmacology

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