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Movento effects on learning and hippocampal brain-derived neurotrophic factor protein of adult male rats.

Movento effects on learning and hippocampal brain-derived neurotrophic factor protein of adult male rats.

Authors :
Zangiabadi I
Afarinesh MR
Shamsara A
Eftekhar-Vaghefi SH
Source :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2019 Dec; Vol. 26 (36), pp. 36615-36622. Date of Electronic Publication: 2019 Nov 16.
Publication Year :
2019

Abstract

Spirotetramat is a toxic commercially known as Movento used to control pistachio psylla pests. In the present study, the effects of Movento on passive avoidance learning of rats and their ability to explore the novel object in the novel object recognition test were investigated. The changes in the concentration of hippocampal brain-derived neurotrophic factor (BDNF) proteins were evaluated, too. Male Wistar rats were gavaged at different dosages of the Movento (50, 100, 250, 500, 1000, 1250, and 1500 mg/kg) or saline for 7 days (administered every 2 days). We showed that Movento caused 50 and 100% mortality at the dose of 1250 and 1500 mg/kg, respectively. At the dose of 1000 mg/kg, Movento significantly decreased locomotor activity (P < 0.05). These rats also displayed a significant decrease in the number of training trials in the shuttle box and the ability to recognize a novel object compared with the control group (P < 0.01). The BDNF protein level of hippocampus also showed a significant decrease in the Movento (1000 mg/kg) compared with the control group (P < 0.01) while the number of pancellular necrosis pyramidal CA1 cells increased significantly in the Movento group (P < 0.001). We concluded that exposure to Movento can decline sensory, motor, and learning in rats.

Details

Language :
English
ISSN :
1614-7499
Volume :
26
Issue :
36
Database :
MEDLINE
Journal :
Environmental science and pollution research international
Publication Type :
Academic Journal
Accession number :
31734837
Full Text :
https://doi.org/10.1007/s11356-019-06809-0