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Association of history of heart failure with hospital outcomes of hyperglycemic crises: Analysis from a University hospital and national cohort.
- Source :
-
Journal of diabetes and its complications [J Diabetes Complications] 2020 Jan; Vol. 34 (1), pp. 107466. Date of Electronic Publication: 2019 Oct 23. - Publication Year :
- 2020
-
Abstract
- Aims: The impact of a history of heart failure (HF) on the outcomes of hospitalization for hyperglycemic crises (diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome) is unknown. We aimed to test the hypothesis that a history of HF has a deleterious impact on the outcomes of hospitalization for hyperglycemic crises.<br />Methods: We used two different datasets: National Inpatient Sample database 2003-2014 and a single University hospital cohort 2007-2017, to identify all adult hospitalizations with a primary diagnosis of hyperglycemic crises. Multivariable regression models were used to analyze the outcomes of in-hospital mortality, length of hospital stay and transfer to nursing home or similar short-term facility between HF and no-HF hospitalizations.<br />Results: Of the 1, 570,726 hyperglycemic crises related hospitalizations, a history of HF was present in 57, 520 (3.6%) hospitalizations. After multivariable risk-adjustment, HF group had a higher observed in-hospital mortality [0.4% vs. 0.2%; adjusted odds ratio (AOR) = 1.7, 95% CI 1.4 to 2.0, P < .001] and transfer to nursing home or similar short-term facility (3.9 vs. 2.8%, AOR = 1.4, 95% CI 1.3 to 1.5, P < .001) compared with no-HF group. Mean length of hospital stay [6.5 vs. 3.5 days; P < .001] was also higher for HF group than no-HF group. Data from the smaller University hospital cohort showed similar findings.<br />Conclusions: Patients with a history of HF may be an under-recognized high-risk group among patients hospitalized for hyperglycemic crisis. Additional studies are warranted to clarify risk elements and optimize the inpatient care of individuals with hyperglycemic crises.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Cohort Studies
Diabetic Ketoacidosis complications
Diabetic Ketoacidosis mortality
Female
Heart Failure complications
Heart Failure mortality
Hospital Mortality
Hospitals, University
Humans
Hyperglycemic Hyperosmolar Nonketotic Coma complications
Hyperglycemic Hyperosmolar Nonketotic Coma mortality
Length of Stay
Male
Middle Aged
Prognosis
Retrospective Studies
Treatment Outcome
United States epidemiology
Young Adult
Diabetic Ketoacidosis diagnosis
Heart Failure diagnosis
Hospitalization statistics & numerical data
Hyperglycemic Hyperosmolar Nonketotic Coma diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1873-460X
- Volume :
- 34
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of diabetes and its complications
- Publication Type :
- Academic Journal
- Accession number :
- 31735638
- Full Text :
- https://doi.org/10.1016/j.jdiacomp.2019.107466