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Hierarchical Ordered Assembly of Genetically Modifiable Viruses into Nanoridge-in-Microridge Structures.
- Source :
-
Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2019 Dec; Vol. 31 (52), pp. e1905577. Date of Electronic Publication: 2019 Nov 18. - Publication Year :
- 2019
-
Abstract
- Hierarchically assembled nanomaterials can find a variety of applications in medicine, energy, and electronics. Here, an automatically controlled dip-pulling method is developed and optimized to generate an unprecedented ordered nano-to-micro hierarchical nanoridge-in-microridge (NiM) structure from a bacteria-specific human-safe virus, the filamentous phage with or without genetically displaying a foreign peptide. The NiM structure is pictured as a window blind with each lath (the microridge) made of parallel phage bundles (the nanoridges). It is independent of the substrate materials supporting it. Surprisingly, it can induce the bidirectional differentiation of stem cells into neurons and astrocytes within a short timeframe (only 8 d) not seen before, which is highly desired because both neurons and astrocytes are needed simultaneously in treating neurodegenerative diseases. Since phages can direct tissue regeneration, template materials formation, sense molecules, and build electrodes, the NiM structures displaying different peptides and on varying materials hold promise in many technologically important fields.<br /> (© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Astrocytes cytology
Astrocytes metabolism
Bacteriophage M13 chemistry
Bacteriophage M13 genetics
Cell Differentiation
Cell Line
Glial Fibrillary Acidic Protein genetics
Glial Fibrillary Acidic Protein metabolism
Humans
Induced Pluripotent Stem Cells cytology
Microscopy, Atomic Force
Nestin genetics
Nestin metabolism
Neural Stem Cells cytology
Neural Stem Cells metabolism
Neurons cytology
Neurons metabolism
Oligopeptides genetics
Oligopeptides metabolism
Polylysine chemistry
Bacteriophage M13 metabolism
Nanostructures chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1521-4095
- Volume :
- 31
- Issue :
- 52
- Database :
- MEDLINE
- Journal :
- Advanced materials (Deerfield Beach, Fla.)
- Publication Type :
- Academic Journal
- Accession number :
- 31736175
- Full Text :
- https://doi.org/10.1002/adma.201905577