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Estimated number of adult survivors of childhood cancer in United States with cancer-predisposing germline variants.
- Source :
-
Pediatric blood & cancer [Pediatr Blood Cancer] 2020 Feb; Vol. 67 (2), pp. e28047. Date of Electronic Publication: 2019 Nov 17. - Publication Year :
- 2020
-
Abstract
- Purpose: To estimate the absolute number of adult survivors of childhood cancer in the U.S. population who carry a pathogenic or likely pathogenic variant in a cancer predisposition gene.<br />Methods: Using the Surveillance, Epidemiology, and End Results (SEER) Program, we estimated the number of childhood cancer survivors on December 31, 2016 for each childhood cancer diagnosis, multiplied this by the proportion of carriers of pathogenic/likely pathogenic variants in the St. Jude Lifetime Cohort (SJLIFE) study, and projected the resulting number onto the U.S.<br />Results: Based on genome sequence data, 11.8% of 2450 SJLIFE participants carry a pathogenic/likely pathogenic variant in one of 156 cancer predisposition genes. Given this information, we estimate that 21 800 adult survivors of childhood cancer in the United States carry a pathogenic/likely pathogenic variant in one of these genes. The highest estimated absolute number of variant carriers are among survivors of central nervous system tumors (n = 4300), particularly astrocytoma (n = 1800) and other gliomas (n = 1700), acute lymphoblastic leukemia (n = 4300), and retinoblastoma (n = 3500). The most frequently mutated genes are RB1 (n = 3000), NF1 (n = 2300), and BRCA2 (n = 800).<br />Conclusion: Given the increasing number of childhood cancer survivors in the United States, clinicians should counsel survivors regarding their potential genetic risk, consider referral for genetic counseling and testing, and, as appropriate, implement syndrome-specific cancer surveillance or risk-reducing measures.<br /> (© 2019 Wiley Periodicals, Inc.)
- Subjects :
- Adolescent
Adult
Aged
Child
Child, Preschool
Cohort Studies
Female
Follow-Up Studies
Humans
Incidence
Infant
Infant, Newborn
Male
Middle Aged
Neoplasms epidemiology
Neoplasms genetics
Prognosis
Risk Factors
Survival Rate
United States epidemiology
Young Adult
Cancer Survivors statistics & numerical data
Genetic Predisposition to Disease
Germ-Line Mutation
Neoplasm Proteins genetics
Neoplasms mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1545-5017
- Volume :
- 67
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Pediatric blood & cancer
- Publication Type :
- Academic Journal
- Accession number :
- 31736278
- Full Text :
- https://doi.org/10.1002/pbc.28047