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The U-shaped association between body mass index and gastric cancer risk in the Helicobacter pylori Biomarker Cohort Consortium: A nested case-control study from eight East Asian cohort studies.
- Source :
-
International journal of cancer [Int J Cancer] 2020 Aug 01; Vol. 147 (3), pp. 777-784. Date of Electronic Publication: 2019 Dec 12. - Publication Year :
- 2020
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Abstract
- The association between body mass index (BMI) and noncardia gastric cancer (NCGC) risk remains controversial. The purpose of our study was to examine the association of BMI with NCGC risk with consideration of Helicobacter pylori (HP) biomarkers. This international nested case-control study, composed of 1,591 incident NCGC cases and 1,953 matched controls, was established from eight cohorts in China, Japan and Korea, where the majority of NCGCs are diagnosed worldwide. HP antibody biomarkers were measured in blood collected at cohort enrollment by multiplex serology. The NCGC risk according to baseline BMI was estimated using logistic regression to produce odds ratios (ORs) and 95% confidence intervals (CIs). We found a U-shaped association between BMI category and NCGC risk. Compared to those with reference BMI (22.6-25.0 kg/m <superscript>2</superscript> ), those with lower and higher BMI had an increased NCGC risk (BMI <18.5 kg/m <superscript>2</superscript> , OR = 1.56, 95% CI = 1.04-2.34; BMI >27.5 kg/m <superscript>2</superscript> , OR = 1.48, 95% CI = 1.15-1.91; adjusted for age, sex and smoking). The U-shaped association was persistent among subjects with HP infection and high-risk biomarkers (HP+ CagA+: BMI <18.5 kg/m <superscript>2</superscript> , OR = 1.60, 95% CI = 1.00-2.55; BMI >27.5 kg/m <superscript>2</superscript> , OR = 1.59, 95% CI = 1.21-2.11; and Omp+ HP0305+: BMI <18.5 kg/m <superscript>2</superscript> , OR = 1.88, 95% CI = 1.04-3.42; BMI >27.5 kg/m <superscript>2</superscript> , OR = 1.70, 95% CI = 1.20-2.42, respectively). Our study provides evidence of significantly increased NCGC risk among individuals with low or high BMI, including in subjects with high-risk HP biomarkers (HP+ CagA+, Omp+ HP0305+) in the high-risk area of East Asia.<br /> (© 2019 UICC.)
- Subjects :
- Aged
Body Mass Index
Case-Control Studies
China epidemiology
Female
Helicobacter Infections complications
Helicobacter Infections immunology
Humans
Japan epidemiology
Logistic Models
Male
Middle Aged
Prospective Studies
Republic of Korea epidemiology
Risk Factors
Stomach Neoplasms etiology
Antibodies, Bacterial blood
Helicobacter Infections epidemiology
Helicobacter pylori immunology
Stomach Neoplasms epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0215
- Volume :
- 147
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 31745972
- Full Text :
- https://doi.org/10.1002/ijc.32790