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Agelanemoechine, a Dimeric Bromopyrrole Alkaloid with a Pro-Angiogenic Effect from the South China Sea Sponge Agelas nemoechinata .

Authors :
Li T
Tang X
Luo X
Wang Q
Liu K
Zhang Y
de Voogd NJ
Yang J
Li P
Li G
Source :
Organic letters [Org Lett] 2019 Dec 06; Vol. 21 (23), pp. 9483-9486. Date of Electronic Publication: 2019 Nov 20.
Publication Year :
2019

Abstract

One new dimeric bromopyrrole alkaloid, agelanemoechine, with an unprecedented imidazo [1,5- a ] azepin nucleus together with one known dimeric bromopyrrole alkaloid sceptrin were isolated from the marine sponge Agelas nemoechinata . The structure elucidation and absolute configuration assignments were determined by extensive spectroscopic analyses and the comparison of experimental and calculated ECD. Agelanemoechine showed strong pro-angiogenic activity in zebrafish.

Details

Language :
English
ISSN :
1523-7052
Volume :
21
Issue :
23
Database :
MEDLINE
Journal :
Organic letters
Publication Type :
Academic Journal
Accession number :
31746608
Full Text :
https://doi.org/10.1021/acs.orglett.9b03683