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Activated PD-1+ CD4+ T cells represent a short-lived part of the viral reservoir and predict poor immunologic recovery upon initiation of ART.
- Source :
-
AIDS (London, England) [AIDS] 2020 Feb 01; Vol. 34 (2), pp. 197-202. - Publication Year :
- 2020
-
Abstract
- Objective: Activated (CD38HLA-DR) PD-1 CD4 T cells are strongly associated with virus replication and disease progression in untreated HIV-1 infection, and viral persistence in individuals on ART. Few studies have examined cell-associated viral load (CAVL) in different activated CD4 T-cell populations to measure relative contributions to viral reservoirs.<br />Design: Longitudinal assessment of HIV-1 chronically infected Ugandans initiating ART, to investigate activated CD4 T-cell populations and their contribution to viral reservoirs.<br />Methods: We followed 32 HIV-1 chronically infected individuals from Kampala, Uganda, and determined their CD4 T-cell counts and viral load at baseline, 6, and 12 months after the initiation of ART. T-cell populations were sorted based on activation profiles and gag DNA was measured to determine CAVL within these populations. Soluble factors associated with inflammation were measured in plasma using a multiplexed platform.<br />Results: Concomitant with viral load decline and CD4 T-cell count rebound, the activated PD-1 CD4 T-cell population contracted upon initiation of ART. Baseline levels of activated PD-1 CD4 T cells correlated with plasma levels of IP-10 and TNFRII. Interestingly, a higher baseline level of activated PD-1 CD4 T cells was associated with poorer CD4 T-cell recovery after 12 months of ART. This population contributed significantly to the cell-associated HIV DNA load at baseline, whereas their contribution declined on ART, indicating high turnover.<br />Conclusion: Activated PD-1 CD4 T cells are predictors of poor immunologic recovery on ART and may represent a short-lived component of HIV-1 reservoirs.
- Subjects :
- Adult
CD4 Lymphocyte Count
Female
HIV Infections immunology
HIV-1 drug effects
Humans
Linear Models
Lymphocyte Activation
Male
RNA, Viral blood
Uganda
Viral Load
Virus Replication drug effects
Anti-Retroviral Agents therapeutic use
CD4-Positive T-Lymphocytes immunology
HIV Infections drug therapy
HIV-1 immunology
Programmed Cell Death 1 Receptor metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5571
- Volume :
- 34
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- AIDS (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 31764072
- Full Text :
- https://doi.org/10.1097/QAD.0000000000002432