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Antioxidant Activity of Tetranitrosyl Iron Complex with Thiosulfate Ligands and Its Effect on Catalytic Activity of Mitochondrial Enzymes In vitro.
- Source :
-
Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2019 Sep; Vol. 488 (1), pp. 342-345. Date of Electronic Publication: 2019 Nov 25. - Publication Year :
- 2019
-
Abstract
- The antioxidant and antiradical properties of the tetra nitrosyl iron complex with thiosulfate ligands (TNIC) were studied in vitro in mouse brain homogenates. It was found for the first time that TNIC is an effective antioxidant. The effect of TNIC on the catalytic activity of mitochondrial enzymes cytochrome c oxidase and monoamine oxidase A was studied. It was shown for the first time that TNIC is an inhibitor of the catalytic activity of cytochrome c oxidase and monoamine oxidase A in animal brain mitochondria in vitro.
- Subjects :
- Animals
Mice
Monoamine Oxidase metabolism
Brain enzymology
Electron Transport Complex IV antagonists & inhibitors
Electron Transport Complex IV metabolism
Iron chemistry
Iron pharmacology
Mitochondria enzymology
Mitochondrial Proteins antagonists & inhibitors
Mitochondrial Proteins metabolism
Monoamine Oxidase Inhibitors chemical synthesis
Monoamine Oxidase Inhibitors chemistry
Monoamine Oxidase Inhibitors pharmacology
Nitrogen Oxides chemical synthesis
Nitrogen Oxides chemistry
Nitrogen Oxides pharmacology
Thiosulfates chemical synthesis
Thiosulfates chemistry
Thiosulfates pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1608-3091
- Volume :
- 488
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Doklady. Biochemistry and biophysics
- Publication Type :
- Academic Journal
- Accession number :
- 31768856
- Full Text :
- https://doi.org/10.1134/S1607672919050120