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The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood.
- Source :
-
Mediators of inflammation [Mediators Inflamm] 2019 Nov 03; Vol. 2019, pp. 7436932. Date of Electronic Publication: 2019 Nov 03 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Background: Matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) contribute to the inflammatory cascade in the cerebrospinal fluid (CSF) during bacterial meningitis. We determined levels of MPO, MMP-8, MMP-9, and tissue inhibitor of metalloproteinase- (TIMP-) 1 in the CSF of children with bacterial meningitis and investigated how these inflammatory mediators relate to each other and to the disease outcomes.<br />Methods: Clinical data and the diagnostic CSF samples from 245 children (median age eight months) with bacterial meningitis were obtained from a clinical trial in Latin America in 1996-2003. MMP-9 levels in the CSF were assessed by zymography, while MMP-8, MPO, and TIMP-1 concentrations were determined with immunofluorometric and enzyme-linked immunosorbent assays.<br />Results: MPO correlated positively with MMP-8 (rho 0.496, P < 0.001) and MMP-9 (rho 0.153, P = 0.02) but negatively with TIMP-1 (rho -0.361, P < 0.001). MMP-8 emerged as the best predictor of disease outcomes: a CSF MMP-8 concentration above the median increased the odds of death 4.9-fold (95% confidence interval 1.8-12.9).<br />Conclusions: CSF MMP-8 presented as an attractive prognostic marker in children with bacterial meningitis.<br />Competing Interests: Prof. Timo Sorsa is an inventor of US patents 5652223, 5736341, 5866432, and 6143476. All the other authors report no conflict of interest.<br /> (Copyright © 2019 Okko Savonius et al.)
- Subjects :
- Adolescent
Adult
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Retrospective Studies
Tissue Inhibitor of Metalloproteinase-1 metabolism
Young Adult
Matrix Metalloproteinase 8 metabolism
Matrix Metalloproteinase 9 metabolism
Meningitis, Bacterial enzymology
Meningitis, Bacterial pathology
Peroxidase metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1466-1861
- Volume :
- 2019
- Database :
- MEDLINE
- Journal :
- Mediators of inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 31780869
- Full Text :
- https://doi.org/10.1155/2019/7436932