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Phytochemical Composition and Bioactive Effects of Salvia africana , Salvia officinalis 'Icterina' and Salvia mexicana Aqueous Extracts.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2019 Nov 27; Vol. 24 (23). Date of Electronic Publication: 2019 Nov 27. - Publication Year :
- 2019
-
Abstract
- In the present study, aqueous extracts of Salvia africana , Salvia officinalis 'Icterina' and Savia mexicana origin were screened for their phenolic composition and for antibacterial, antioxidant, anti-inflammatory and cytotoxic properties. The three aqueous extracts contained distinct phenolic compounds, with S. africana presenting the highest total levels (231.6 ± 7.5 μg/mg). Rosmarinic acid was the dominant phenolic compound in all extracts, yet that of S. africana origin was characterized by the present of yunnaneic acid isomers, which overall accounted for about 40% of total phenolics. In turn, S. officinalis 'Icterina' extract presented glycosidic forms of apigenin, luteolin and scuttelarein, and the one obtained from S. mexicana contained several simple caffeic acid derivatives. S. africana aqueous extract exhibited high antioxidant potential in four methods, namely the DPPH <superscript>•</superscript> (2,2-diphenyl-1-picrylhydrazyl) scavenging ability, iron-reducing power, inhibition of β-carotene bleaching and of thiobarbituric acid reactive substances (TBARS), for which EC <subscript>50</subscript> values were equal or only 1.3-3.1 higher than those of the standard compounds. Moreover, this extract was able to lower the levels of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages (EC <subscript>50</subscript> = 47.8 ± 2.1 μg/mL). In addition, the three sage aqueous extracts showed promising cytotoxic effect towards hepatocellular HepG2, cervical HeLa, and breast carcinoma cells MCF-7. Overall this study highlights the potential of three little-exploited Salvia species, with commercial value for applications in food or pharmaceutical industries.
- Subjects :
- Anti-Bacterial Agents pharmacology
Anti-Inflammatory Agents pharmacology
Antioxidants chemistry
Biphenyl Compounds chemistry
Biphenyl Compounds pharmacology
Camphanes
Cinnamates chemistry
Cytotoxins pharmacology
Depsides chemistry
Free Radical Scavengers pharmacology
HeLa Cells
Hep G2 Cells
Humans
MCF-7 Cells
Panax notoginseng
Phenols chemistry
Phytochemicals
Picrates chemistry
Picrates pharmacology
Salvia miltiorrhiza
Salvia officinalis metabolism
Rosmarinic Acid
Drugs, Chinese Herbal chemistry
Drugs, Chinese Herbal pharmacology
Phenols analysis
Salvia officinalis chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 24
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 31783509
- Full Text :
- https://doi.org/10.3390/molecules24234327