Back to Search
Start Over
Hyperventilation-induced heart rate response as a potential marker for cardiovascular disease.
- Source :
-
Scientific reports [Sci Rep] 2019 Nov 29; Vol. 9 (1), pp. 17887. Date of Electronic Publication: 2019 Nov 29. - Publication Year :
- 2019
-
Abstract
- An increase of heart rate to physical or mental stress reflects the ability of the autonomous nervous system and the heart to respond adequately. Hyperventilation is a user-controlled breathing maneuver that has a significant impact on coronary function and hemodynamics. Thus, we aimed to investigate if the heart rate response to hyperventilation (HRR <subscript>HV</subscript> ) can provide clinically useful information. A pooled analysis of the HRR <subscript>HV</subscript> after 60 s of hyperventilation was conducted in 282 participants including healthy controls; patients with heart failure (HF); coronary artery disease (CAD); a combination of both; or patients suspected of CAD but with a normal angiogram. Hyperventilation significantly increased heart rate in all groups, although healthy controls aged 55 years and older (15 ± 9 bpm) had a larger HRR <subscript>HV</subscript> than each of the disease groups (HF: 6 ± 6, CAD: 8 ± 8, CAD+/HF+: 6 ± 4, and CAD-/HF-: 8 ± 6 bpm, p < 0.001). No significant differences were found between disease groups. The HRR <subscript>HV</subscript> may serve as an easily measurable additional marker of cardiovascular health. Future studies should test its diagnostic potential as a simple, inexpensive pre-screening test to improve patient selection for other diagnostic exams.
- Subjects :
- Adrenergic beta-Antagonists pharmacology
Adrenergic beta-Antagonists therapeutic use
Adult
Biomarkers analysis
Cardiovascular Diseases drug therapy
Case-Control Studies
Female
Heart Failure diagnosis
Heart Rate drug effects
Humans
Male
Middle Aged
Sensitivity and Specificity
Cardiovascular Diseases diagnosis
Heart Rate physiology
Hyperventilation physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 31784617
- Full Text :
- https://doi.org/10.1038/s41598-019-54375-9