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Experiencia con el uso de olaparib en pacientes con cáncer de ovario.
- Source :
-
Gaceta medica de Mexico [Gac Med Mex] 2019; Vol. 155 (6), pp. 585-589. - Publication Year :
- 2019
-
Abstract
- Introduction: More than the twenty percent of ovarian cancers are hereditary, and most have BRCA mutations. The 30% of Mexican patients with the BRCA1 mutation have the BRCA1 gene exon 9-12del deletion founder mutation (BRCA1 ex9-12del). BRCA-mutated tumors are more sensitive to PARP inhibitors such as olaparib.<br />Objective: To show the clinical experience on the use of olaparib at Instituto Nacional de Cancerología in Mexico.<br />Method: Ovarian cancer patients treated with olaparib from November 2016 to December 2018 were studied, and their characteristics, clinical response, progression-free survival (PFS) and toxicities were described.<br />Results: Nineteen patients were assessed, with BRCA1 mutation being found in 78.9%, out of which 21.1% were carriers of the ex9-12del founder mutation. The median of PFS was 12 months; for patients treated on second and third line it was > 15 months, and for those treated with a fourth and subsequent line it was 8.3 months. Patients with the founder mutation had better results. Toxicities were like those reported in previous studies.<br />Conclusions: Olaparib offers greater PFS benefit as maintenance therapy after a first and second relapse. Patients with founder mutation have had sustained PFS.<br /> (Copyright: © 2019 Permanyer.)
- Subjects :
- Adult
Aged
Female
Humans
Mexico
Middle Aged
Mutation
Neoplasm Recurrence, Local
Ovarian Neoplasms genetics
Ovarian Neoplasms pathology
Phthalazines adverse effects
Piperazines adverse effects
Poly(ADP-ribose) Polymerase Inhibitors adverse effects
Progression-Free Survival
BRCA1 Protein genetics
Ovarian Neoplasms drug therapy
Phthalazines administration & dosage
Piperazines administration & dosage
Poly(ADP-ribose) Polymerase Inhibitors administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0016-3813
- Volume :
- 155
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Gaceta medica de Mexico
- Publication Type :
- Academic Journal
- Accession number :
- 31787769
- Full Text :
- https://doi.org/10.24875/GMM.19005494