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A lipase-responsive antifungal nanoplatform for synergistic photodynamic/photothermal/pharmaco-therapy of azole-resistant Candida albicans infections.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2019 Dec 28; Vol. 55 (100), pp. 15145-15148. Date of Electronic Publication: 2019 Dec 02. - Publication Year :
- 2019
-
Abstract
- A lipase-triggered drug release nanoplatform (PGL-DPP-FLU NPs) for multi-modal antifungal therapy is developed. The lipases secreted by C. albicans can accelerate FLU release. The ROS and heat produced by PGL-DPP-FLU NPs make C. albicans more vulnerable to FLU, thereby PGL-DPP-FLU NPs exhibit high performance for combating azole-resistant C. albicans biofilms and wound infection.
- Subjects :
- Animals
Antifungal Agents chemistry
Antifungal Agents therapeutic use
Azoles pharmacology
Candidiasis drug therapy
Candidiasis pathology
Candidiasis veterinary
Drug Resistance, Fungal drug effects
Ethylene Glycols chemistry
Fluconazole chemistry
Ketones chemistry
Lasers
Mice
Photochemotherapy
Phototherapy
Polyesters chemistry
Pyrroles chemistry
Antifungal Agents pharmacology
Azoles chemistry
Candida albicans drug effects
Lipase metabolism
Nanoparticles chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 55
- Issue :
- 100
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 31790115
- Full Text :
- https://doi.org/10.1039/c9cc08463k